Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …

Abstract G-quadruplex (G4) with stacked G-tetrads structure is able to bind hemin (iron (III)-
protoporphyrin IX) to form a unique type of DNAzyme/RNAzyme with peroxidase-mimicking …

Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and
photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report a …

Nucleic acids play crucial roles in transferring cellular information and gene regulations.
DNA and RNA molecules have been associated with multiple human diseases and thus …

Enzymes have been widely applied for green transformation in a variety of fields due to their
remarkable catalytic properties, which are largely attributed to the spatial arrangement of the …

Enzymes fold into three-dimensional structures to distribute amino acid residues for
catalysis, which inspired the supramolecular approach to construct enzyme-mimicking …

Abstract G-quadruplex (G4)/hemin DNAzyme is promising horseradish peroxidase (HRP)-
mimic candidate in the biological field. However, its relatively unsatisfactory catalytic …

Conspectus Central to the quest of understanding the emergence of life is to uncover the
role of metals, particularly iron, in sha** prebiotic chemistry. Iron, as the most abundant of …

Photodynamic therapy (PDT) has emerged as a promising tumor treatment method via light-
triggered generation of reactive oxygen species (ROS) to kill tumor cells. However, the …