Remyelination in multiple sclerosis: findings in the cuprizone model
H Leo, M Kipp - International Journal of Molecular Sciences, 2022 - mdpi.com
Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …
Assessing disease progression and treatment response in progressive multiple sclerosis
G Comi, G Dalla Costa, B Stankoff… - Nature Reviews …, 2024 - nature.com
Progressive multiple sclerosis poses a considerable challenge in the evaluation of disease
progression and treatment response owing to its multifaceted pathophysiology. Traditional …
progression and treatment response owing to its multifaceted pathophysiology. Traditional …
Remyelination protects neurons from DLK-mediated neurodegeneration
GJ Duncan, SD Ingram, K Emberley, J Hill… - Nature …, 2024 - nature.com
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the
degeneration of neurons and their connections that drives progressive disability in …
degeneration of neurons and their connections that drives progressive disability in …
Comparison of diffusion tensor imaging (DTI) tissue characterization parameters in white matter tracts of patients with multiple sclerosis (MS) and neuromyelitis optica …
X Chen, N Roberts, Q Zheng, Y Peng, Y Han, Q Luo… - European …, 2024 - Springer
Objective To investigate the microstructural properties of T2 lesion and normal-appearing
white matter (NAWM) in 20 white matter tracts between multiple sclerosis (MS) and …
white matter (NAWM) in 20 white matter tracts between multiple sclerosis (MS) and …
Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination
AG de la Fuente, M Dittmer, EJ Heesbeen… - Nature …, 2024 - nature.com
Myelin regeneration (remyelination) is essential to prevent neurodegeneration in
demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age …
demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age …
Efficacy of a benzothiazole‐based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
R Benítez‐Fernández, F Josa‐Prado… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Multiple sclerosis (MS) is a chronic neurological disease that currently lacks effective
curative treatments. There is a need to find effective therapies, especially to reverse the …
curative treatments. There is a need to find effective therapies, especially to reverse the …
Advanced MRI Measures of Myelin and Axon Volume Identify Repair in Multiple Sclerosis
Objective Pathological studies suggest that multiple sclerosis (MS) lesions endure multiple
waves of damage and repair; however, the dynamics and characteristics of these processes …
waves of damage and repair; however, the dynamics and characteristics of these processes …
Clinically relevant profiles of myelin content changes in patients with multiple sclerosis: A multimodal and multicompartment imaging study
Objective: To investigate the clinical relevance of individual profiles of cortical and white
matter lesion myelin content changes combining magnetisation transfer imaging (MTI) and …
matter lesion myelin content changes combining magnetisation transfer imaging (MTI) and …
Changes of brain parenchyma free water fraction reflect tissue damage and impaired processing speed in multiple sclerosis
Free water fraction (FWF) represents the amount of water per unit volume of brain
parenchyma, which is not bound to macromolecules. Its excess in multiple sclerosis (MS) is …
parenchyma, which is not bound to macromolecules. Its excess in multiple sclerosis (MS) is …
Women in the field of multiple sclerosis: How they contributed to paradigm shifts
A Barateiro, C Barros, MV Pinto, AR Ribeiro… - Frontiers in Molecular …, 2023 - frontiersin.org
History is full of women who made enormous contributions to science. While there is little to
no imbalance at the early career stage, a decreasing proportion of women is found as …
no imbalance at the early career stage, a decreasing proportion of women is found as …