Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …

Background In order to improve injury assessment of brain injuries, protein markers of
pathophysiological processes and tissue fate have been introduced in the clinic. The most …

Background The burden of traumatic brain injury (TBI) poses a large public health and
societal problem, but the characteristics of patients and their care pathways in Europe are …

Background After traumatic brain injury (TBI), plasma concentration of glial fibrillary acidic
protein (GFAP) correlates with intracranial injury visible on CT scan. Some patients with …

Background The proteins S100B, neuron-specific enolase (NSE), glial fibrillary acidic
protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and neurofilament light …

Brain-enriched protein biomarkers of tissue fate are being introduced clinically to aid in
traumatic brain injury (TBI) management. The aim of this study was to determine how …

Biomarkers can be broadly defined as qualitative or quantitative measurements that convey
information on the physiopathological state of a subject at a certain time point or disease …

There is growing public concern surrounding traumatic brain injury (TBI). TBI can cause
significant morbidity, and the long-term sequelae are poorly understood. TBI diagnosis and …

Background In order to improve assessment and outcome prediction in patients suffering
from traumatic brain injury (TBI), cerebral protein levels in serum have been suggested as …

Introduction A blood-based biomarker (BBBM) test could help to better stratify patients with
traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary …