Most organisms evolved endogenous, so called circadian clocks as internal timekee**
mechanisms allowing them to adapt to recurring changes in environmental demands …

Circadian clocks confer 24-h periodicity to biological systems, to ultimately maximize energy
efficiency and promote survival in a world with regular environmental light cycles. In …

To maintain energy homeostasis despite variable energy supply and consumption along the
diurnal cycle, the liver relies on a circadian clock synchronized to food timing. Perturbed …

Generalized anxiety and major depression have become increasingly common in the United
States, affecting 18.6 percent of the adult population. Mood disorders can be debilitating …

Gene regulatory feedback loops generate autonomous circadian rhythms in mammalian
tissues. The well-studied core clock network contains many negative and positive …

The circadian (∼ 24h) clock is based on a negative-feedback loop centered around the
PERIOD protein (PER), translated in the cytoplasm and then enters the nucleus to repress its …

Simple Summary Personalized cancer treatments show decreased side-effects and
improved treatment success. One aspect of individualized treatment is the timing of medicine …

The molecular oscillator of the mammalian circadian clock consists in a dynamical network
of genes and proteins whose main regulatory mechanisms occur at the transcriptional level …

Altered working and slee** schedules during the COVID-19 pandemic likely impact our
circadian systems. At the molecular level, clock genes form feedback inhibition loops that …

The term energy metabolism comprises the entirety of chemical processes associated with
uptake, conversion, storage, and breakdown of nutrients. All these must be tightly regulated …