The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Tumor angiogenesis: causes, consequences, challenges and opportunities
R Lugano, M Ramachandran, A Dimberg - Cellular and Molecular Life …, 2020 - Springer
Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …
vary between tumor type and anatomic location, but also occur simultaneously within the …
Development, maintenance and disruption of the blood-brain barrier
The interface between the blood circulation and the neural tissue features unique
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …
[HTML][HTML] Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators
of vascular morphogenesis and function during development, cardiovascular homeostasis …
of vascular morphogenesis and function during development, cardiovascular homeostasis …
Blood-brain barrier dysfunction and recovery after ischemic stroke
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
Vascular-specific growth factors and blood vessel formation
GD Yancopoulos, S Davis, NW Gale, JS Rudge… - nature, 2000 - nature.com
A recent explosion in newly discovered vascular growth factors has coincided with
exploitation of powerful new genetic approaches for studying vascular development. An …
exploitation of powerful new genetic approaches for studying vascular development. An …
Role of platelet-derived growth factors in physiology and medicine
J Andrae, R Gallini, C Betsholtz - Genes & development, 2008 - genesdev.cshlp.org
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …
Transport of drugs from blood vessels to tumour tissue
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
Bone marrow stromal stem cells: nature, biology, and potential applications
Bone marrow stromal cells are progenitors of skeletal tissue components such as bone,
cartilage, the hematopoiesis-supporting stroma, and adipocytes. In addition, they may be …
cartilage, the hematopoiesis-supporting stroma, and adipocytes. In addition, they may be …
Endothelial/pericyte interactions
Interactions between endothelial cells and mural cells (pericytes and vascular smooth
muscle cells) in the blood vessel wall have recently come into focus as central processes in …
muscle cells) in the blood vessel wall have recently come into focus as central processes in …