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Genetic contributions to anxiety disorders: where we are and where we are heading
Anxiety disorders are among the most common psychiatric disorders worldwide. They often
onset early in life, with symptoms and consequences that can persist for decades. This …
onset early in life, with symptoms and consequences that can persist for decades. This …
Gene-gene interaction: the curse of dimensionality
Identified genetic variants from genome wide association studies frequently show only
modest effects on the disease risk, leading to the “missing heritability” problem. An avenue …
modest effects on the disease risk, leading to the “missing heritability” problem. An avenue …
A local score approach improves GWAS resolution and detects minor QTL: application to Medicago truncatula quantitative disease resistance to multiple …
Quantitative trait loci (QTL) with small effects, which are pervasive in quantitative phenotypic
variation, are difficult to detect in genome-wide association studies (GWAS). To improve their …
variation, are difficult to detect in genome-wide association studies (GWAS). To improve their …
[HTML][HTML] Deciphering the genetic architecture of plant virus resistance by GWAS, state of the art and potential advances
S Monnot, H Desaint, T Mary-Huard, L Moreau… - Cells, 2021 - mdpi.com
Growing virus resistant varieties is a highly effective means to avoid yield loss due to
infection by many types of virus. The challenge is to be able to detect resistance donors …
infection by many types of virus. The challenge is to be able to detect resistance donors …
Contribution of circulating Mfge8 to human T2DM and cardiovascular disease
MFGE8 is a major exosome (EV) protein known to mediate inflammation and atherosclerosis
in type 2 diabetes mellitus (T2DM) in animal studies. The pathophysiological role of this …
in type 2 diabetes mellitus (T2DM) in animal studies. The pathophysiological role of this …
Association between Interleukin‐6 Gene Polymorphism (rs1800795 and rs1800796) and Type 2 Diabetes Mellitus in a Ghanaian Population: A Case‐Control Study …
Background. There is no conclusive evidence on the association between interleukin‐(IL‐) 6
gene polymorphism and type 2 diabetes mellitus (type 2 DM). Thus, this study is aimed at …
gene polymorphism and type 2 diabetes mellitus (type 2 DM). Thus, this study is aimed at …
Association study and mutation sequencing of genes on chromosome 15q11-q13 identified GABRG3 as a susceptibility gene for autism in Chinese Han population
L Wang, J Li, M Shuang, T Lu, Z Wang, T Zhang… - Translational …, 2018 - nature.com
Cytogenetic studies suggested that chromosome 15q11-q13 might be a candidate region
that increases the risk of autism. Previous association studies in Caucasian populations …
that increases the risk of autism. Previous association studies in Caucasian populations …
Genetic and epigenetic analyses of panic disorder in the post-GWAS era
Y Morimoto, S Ono, N Kurotaki, A Imamura… - Journal of Neural …, 2020 - Springer
Panic disorder (PD) is a common and debilitating neuropsychiatric disorder characterized by
panic attacks coupled with excessive anxiety. Both genetic factors and environmental factors …
panic attacks coupled with excessive anxiety. Both genetic factors and environmental factors …
Progressive effects of single-nucleotide polymorphisms on 16 phenotypic traits based on longitudinal data
Background There are many research studies have estimated the heritability of phenotypic
traits, but few have considered longitudinal changes in several phenotypic traits together …
traits, but few have considered longitudinal changes in several phenotypic traits together …
Weighted multiple testing procedures in genome-wide association studies
L Obry, C Dalmasso - PeerJ, 2023 - peerj.com
Multiple testing procedures controlling the false discovery rate (FDR) are increasingly used
in the context of genome wide association studies (GWAS), and weighted multiple testing …
in the context of genome wide association studies (GWAS), and weighted multiple testing …