Genetic contributions to anxiety disorders: where we are and where we are heading

H Ask, R Cheesman, ES Jami, DF Levey… - Psychological …, 2021 - cambridge.org
Anxiety disorders are among the most common psychiatric disorders worldwide. They often
onset early in life, with symptoms and consequences that can persist for decades. This …

Gene-gene interaction: the curse of dimensionality

A Chattopadhyay, TP Lu - Annals of translational medicine, 2019 - pmc.ncbi.nlm.nih.gov
Identified genetic variants from genome wide association studies frequently show only
modest effects on the disease risk, leading to the “missing heritability” problem. An avenue …

A local score approach improves GWAS resolution and detects minor QTL: application to Medicago truncatula quantitative disease resistance to multiple …

M Bonhomme, MI Fariello, H Navier, A Hajri, Y Badis… - Heredity, 2019 - nature.com
Quantitative trait loci (QTL) with small effects, which are pervasive in quantitative phenotypic
variation, are difficult to detect in genome-wide association studies (GWAS). To improve their …

[HTML][HTML] Deciphering the genetic architecture of plant virus resistance by GWAS, state of the art and potential advances

S Monnot, H Desaint, T Mary-Huard, L Moreau… - Cells, 2021 - mdpi.com
Growing virus resistant varieties is a highly effective means to avoid yield loss due to
infection by many types of virus. The challenge is to be able to detect resistance donors …

Contribution of circulating Mfge8 to human T2DM and cardiovascular disease

M Rout, MW Malone-Perez, G Park, M Lerner… - Gene, 2024 - Elsevier
MFGE8 is a major exosome (EV) protein known to mediate inflammation and atherosclerosis
in type 2 diabetes mellitus (T2DM) in animal studies. The pathophysiological role of this …

Association between Interleukin‐6 Gene Polymorphism (rs1800795 and rs1800796) and Type 2 Diabetes Mellitus in a Ghanaian Population: A Case‐Control Study …

C Obirikorang, SY Lokpo… - BioMed Research …, 2024 - Wiley Online Library
Background. There is no conclusive evidence on the association between interleukin‐(IL‐) 6
gene polymorphism and type 2 diabetes mellitus (type 2 DM). Thus, this study is aimed at …

Association study and mutation sequencing of genes on chromosome 15q11-q13 identified GABRG3 as a susceptibility gene for autism in Chinese Han population

L Wang, J Li, M Shuang, T Lu, Z Wang, T Zhang… - Translational …, 2018 - nature.com
Cytogenetic studies suggested that chromosome 15q11-q13 might be a candidate region
that increases the risk of autism. Previous association studies in Caucasian populations …

Genetic and epigenetic analyses of panic disorder in the post-GWAS era

Y Morimoto, S Ono, N Kurotaki, A Imamura… - Journal of Neural …, 2020 - Springer
Panic disorder (PD) is a common and debilitating neuropsychiatric disorder characterized by
panic attacks coupled with excessive anxiety. Both genetic factors and environmental factors …

Progressive effects of single-nucleotide polymorphisms on 16 phenotypic traits based on longitudinal data

D Li, H Kang, S Lee, S Won - Genes & genomics, 2020 - Springer
Background There are many research studies have estimated the heritability of phenotypic
traits, but few have considered longitudinal changes in several phenotypic traits together …

Weighted multiple testing procedures in genome-wide association studies

L Obry, C Dalmasso - PeerJ, 2023 - peerj.com
Multiple testing procedures controlling the false discovery rate (FDR) are increasingly used
in the context of genome wide association studies (GWAS), and weighted multiple testing …