The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …
genetic associations with such disorders, but better methods are needed to derive the …
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-map** in HIV host response
Fine-map** to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …
particularly in the MHC, which has population-specific structure. To enable such studies, we …
HIV-1 and human genetic variation
PJ McLaren, J Fellay - Nature Reviews Genetics, 2021 - nature.com
Over the past four decades, research on the natural history of HIV infection has described
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …
Ageing and inflammation in patients with HIV infection
Nowadays, HIV+ patients have an expected lifespan that is only slightly shorter than healthy
individuals. For this reason, along with the fact that infection can be acquired at a relatively …
individuals. For this reason, along with the fact that infection can be acquired at a relatively …
Africa-specific human genetic variation near CHD1L associates with HIV-1 load
PJ McLaren, I Porreca, G Iaconis, HP Mok… - Nature, 2023 - nature.com
HIV-1 remains a global health crisis, highlighting the need to identify new targets for
therapies. Here, given the disproportionate HIV-1 burden and marked human genome …
therapies. Here, given the disproportionate HIV-1 burden and marked human genome …
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
Background Humoral immune responses to infectious agents or vaccination vary
substantially among individuals, and many of the factors responsible for this variability …
substantially among individuals, and many of the factors responsible for this variability …
The impact of host genetic variation on infection with HIV-1
PJ McLaren, M Carrington - Nature immunology, 2015 - nature.com
The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a
complex phenotype determined by interactions among the pathogen, the human host and …
complex phenotype determined by interactions among the pathogen, the human host and …
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
PJ McLaren, C Coulonges, I Bartha… - Proceedings of the …, 2015 - National Acad Sciences
Previous genome-wide association studies (GWAS) of HIV-1–infected populations have
been underpowered to detect common variants with moderate impact on disease outcome …
been underpowered to detect common variants with moderate impact on disease outcome …