The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is
used increasingly in human studies. However, direct analyses to address the relative …

Background Periprosthetic joint infection (PJI) is a devastating complication after total hip
arthroplasty (THA) or total knee arthroplasty (TKA). It is scarce and contradicting evidence …

Integrating genetic information with metabolomics has provided new insights into genes
affecting human metabolism. However, gene-metabolite integration has been primarily …

Background: Plasma proteins are critical mediators of cardiovascular processes and are the
targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma …

Background Understanding the impact of clonal hematopoiesis of indeterminate potential
(CHIP) and mosaic chromosomal alterations (mCAs) on solid tumor risk and mortality can …

Although many novel gene-metabolite and gene-protein associations have been identified
using high-throughput biochemical profiling, systematic studies that leverage human …

Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce
severe inflammation and activation of the coagulation system, resulting in a prothrombotic …

Objective: Abnormal elevation of D-dimer levels is an important indicator of disseminated
intravascular clotting. Therefore, we hypothesized that high D-dimer levels were associated …

With the evolution of the COVID‐19 pandemic, there is now a need for point‐of‐care devices
for the quantification of disease biomarkers toward disease severity assessment. Disease …