[HTML][HTML] Principles for targeting RNA with drug-like small molecules
KD Warner, CE Hajdin, KM Weeks - Nature reviews Drug discovery, 2018 - nature.com
RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
The roles of structural dynamics in the cellular functions of RNAs
RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning
The majority of our human genome transcribes into noncoding RNAs with unknown
structures and functions. Obtaining functional clues for noncoding RNAs requires accurate …
structures and functions. Obtaining functional clues for noncoding RNAs requires accurate …
RNA structural dynamics as captured by molecular simulations: a comprehensive overview
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
Solute–solvent interactions in modern physical organic chemistry: Supramolecular polymers as a muse
MFJ Mabesoone, ARA Palmans… - Journal of the American …, 2020 - ACS Publications
Interactions between solvents and solutes are a cornerstone of physical organic chemistry
and have been the subject of investigations over the last century. In recent years, a renewed …
and have been the subject of investigations over the last century. In recent years, a renewed …
RNAs undergo phase transitions with lower critical solution temperatures
Co-phase separation of RNAs and RNA-binding proteins drives the biogenesis of
ribonucleoprotein granules. RNAs can also undergo phase transitions in the absence of …
ribonucleoprotein granules. RNAs can also undergo phase transitions in the absence of …
Catalytic DNA: scope, applications, and biochemistry of deoxyribozymes
SK Silverman - Trends in biochemical sciences, 2016 - cell.com
The discovery of natural RNA enzymes (ribozymes) prompted the pursuit of artificial DNA
enzymes (deoxyribozymes) by in vitro selection methods. A key motivation is the conceptual …
enzymes (deoxyribozymes) by in vitro selection methods. A key motivation is the conceptual …
The thermodynamics of DNA structural motifs
J SantaLucia Jr, D Hicks - Annu. Rev. Biophys. Biomol. Struct., 2004 - annualreviews.org
▪ Abstract DNA secondary structure plays an important role in biology, genoty**
diagnostics, a variety of molecular biology techniques, in vitro–selected DNA catalysts …
diagnostics, a variety of molecular biology techniques, in vitro–selected DNA catalysts …
RNAstructure: web servers for RNA secondary structure prediction and analysis
S Bellaousov, JS Reuter, MG Seetin… - Nucleic acids …, 2013 - academic.oup.com
RNAstructure is a software package for RNA secondary structure prediction and analysis.
This contribution describes a new set of web servers to provide its functionality. The web …
This contribution describes a new set of web servers to provide its functionality. The web …
Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …