The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

The crystalline lens is a transparent and refractive biconvex structure formed by lens
epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading …

Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

The DNA-binding transcription factor PAX6 was cloned 25 years ago by multiple teams
pursuing identification of human and mouse eye disease causing genes, cloning vertebrate …

In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …

Cataract is a common age-related condition that is caused by progressive clouding of the
normally clear lens. Cataract can be effectively treated by surgery; however, like any …