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Ribosome biogenesis factors—from names to functions
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
DB Chou, V Frismantas, Y Milton, R David… - Nature biomedical …, 2020 - nature.com
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology
under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show …
under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show …
An overview of pre‐ribosomal RNA processing in eukaryotes
Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …
Uncovering the assembly pathway of human ribosomes and its emerging links to disease
KE Bohnsack, MT Bohnsack - The EMBO journal, 2019 - embopress.org
The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …
Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae
JL Woolford Jr, SJ Baserga - Genetics, 2013 - academic.oup.com
Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …
in the genome to create the proteome in all cells. In yeast these complex particles contain …
Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Z Turi, M Lacey, M Mistrik, P Moudry - Aging (Albany NY), 2019 - pmc.ncbi.nlm.nih.gov
The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …
many factors and a huge energy investment from the cell. Ribosomes are essential for …
Hallmarks of ribosomopathies
Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with
a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical …
a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical …
Mesenchymal inflammation drives genotoxic stress in hematopoietic stem cells and predicts disease evolution in human pre-leukemia
Mesenchymal niche cells may drive tissue failure and malignant transformation in the
hematopoietic system, but the underlying molecular mechanisms and relevance to human …
hematopoietic system, but the underlying molecular mechanisms and relevance to human …
The structure and function of the eukaryotic ribosome
Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …