Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of
cholesterol metabolism contributes to the pathogenesis of various diseases including …

The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum
(ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol …

Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and inflammation
in the central nervous system (CNS). The brain, which contains a disproportionately large …

Background The development of new treatment strategies to improve peripheral nerve
repair after injury, especially those that accelerate axonal nerve regeneration, is very …

Accelerated cholesterol and lipid metabolism are the hallmarks of cancer and contribute to
malignant transformation due to the obligatory requirement for cholesterol for the function of …

Endocytosis is a fundamental mechanism by which cells perform housekee** functions. It
occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase …