Risk factors for childhood obesity in the first 1,000 days: a systematic review
Context Mounting evidence suggests that the origins of childhood obesity and related
disparities can be found as early as the “first 1,000 days”—the period from conception to age …
disparities can be found as early as the “first 1,000 days”—the period from conception to age …
The bigger picture of FTO—the first GWAS-identified obesity gene
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …
obesity associated (FTO) gene are associated obesity traits in genome-wide association …
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
An atlas of genetic correlations across human diseases and traits
Identifying genetic correlations between complex traits and diseases can provide useful
etiological insights and help prioritize likely causal relationships. The major challenges …
etiological insights and help prioritize likely causal relationships. The major challenges …
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …
obesity better, here we conduct a genome-wide association study and Metabochip meta …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and …
Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of …
association study (GWAS) summary-level results data to estimate the SNP heritability of …
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
AG Baltz, M Munschauer, B Schwanhäusser, A Vasile… - Molecular cell, 2012 - cell.com
Protein-RNA interactions are fundamental to core biological processes, such as mRNA
splicing, localization, degradation, and translation. We developed a photoreactive …
splicing, localization, degradation, and translation. We developed a photoreactive …
Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …