Role of endoplasmic reticulum stress-related unfolded protein response and its implications in dengue virus infection for biomarker development

B Das, S Samal, H Hamdi, A Pal, A Biswas, J Behera… - Life Sciences, 2023 - Elsevier
Dengue virus (DENV) causes debilitating disease in humans, which varies at different rates
in host cells, such as monocytes, macrophages, dendritic cells, Langerhans cells, and other …

Mosquito antiviral immune pathways

CV Tikhe, G Dimopoulos - Developmental & Comparative Immunology, 2021 - Elsevier
Mosquitoes are vectors of a large number of viral pathogens. In recent years, increased
urbanization and climate change has expanded the range of many vector mosquitoes. The …

Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host

BW Wei **ang, WAA Saron… - Proceedings of the …, 2022 - National Acad Sciences
Mosquito blood-feeding behavior is a key determinant of the epidemiology of dengue
viruses (DENV), the most-prevalent mosquito-borne viruses. However, despite its …

PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection

S Wang, H Guo, K Zhu-Salzman, F Ge, Y Sun - Nature Communications, 2022 - nature.com
Apoptosis and autophagy are two common forms of programmed cell death (PCD) used by
host organisms to fight against virus infection. PCD in arthropod vectors can be manipulated …

High resolution proteomics of Aedes aegypti salivary glands infected with either dengue, Zika or chikungunya viruses identify new virus specific and broad antiviral …

A Chowdhury, CM Modahl, D Missé, RM Kini… - Scientific Reports, 2021 - nature.com
Arboviruses such as dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses infect
close to half a billion people per year, and are primarily transmitted through Aedes aegypti …

Uncovering the Worldwide Diversity and Evolution of the Virome of the Mosquitoes Aedes aegypti and Aedes albopictus

R Parry, ME James, S Asgari - Microorganisms, 2021 - mdpi.com
Aedes aegypti, the yellow fever mosquito, and Aedes albopictus, the Asian tiger mosquito,
are the most significant vectors of dengue, Zika, and Chikungunya viruses globally. Studies …

The JAK-STAT pathway promotes persistent viral infection by activating apoptosis in insect vectors

Y Zhang, BX Li, QZ Mao, JC Zhuo, HJ Huang… - PLoS …, 2023 - journals.plos.org
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is an
evolutionarily conserved signaling pathway that can regulate various biological processes …

Recognition of arboviruses by the mosquito immune system

BC Prince, E Walsh, TZB Torres, C Rückert - Biomolecules, 2023 - mdpi.com
Arthropod-borne viruses (arboviruses) pose a significant threat to both human and animal
health worldwide. These viruses are transmitted through the bites of mosquitoes, ticks …

Apoptosis and autophagy: current understanding in tick–pathogen interactions

XR Wang, B Cull - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Tick-borne diseases are a significant threat to human and animal health throughout the
world. How tick-borne pathogens successfully infect and disseminate in both their vertebrate …

The role of mosquito hemocytes in viral infections

V Cardoso-Jaime, CV Tikhe, S Dong, G Dimopoulos - Viruses, 2022 - mdpi.com
Insect hemocytes are the only immune cells that can mount a humoral and cellular immune
response. Despite the critical involvement of hemocytes in immune responses against …