DNA methylation in mammalian development and disease
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …
characterization to one seeking deeper functional understanding of how this modification …
Regulation, functions and transmission of bivalent chromatin during mammalian development
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
[HTML][HTML] The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes
The mobility of transposable elements (TEs) contributes to evolution of genomes. Their
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …
Sex differences in the intergenerational inheritance of metabolic traits
Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …
including those in utero, influence our long-term metabolic health. This has been termed …
Epigenetic resetting in the human germ line entails histone modification remodeling
Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which
lays the foundation for gametogenesis, totipotency, and embryonic development. We …
lays the foundation for gametogenesis, totipotency, and embryonic development. We …
Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells
X Zhao, X Li, H Sun, X Zhao, T Gao, P Shi… - Nucleic Acids …, 2023 - academic.oup.com
Dot1l is a histone methyltransferase without a SET domain and is responsible for H3K79
methylation, which marks active transcription. In contradiction, Dot1l also participates in …
methylation, which marks active transcription. In contradiction, Dot1l also participates in …
WITHDRAWN: An OPA-F-Based Single-Valued Neutrosophic Fuzzy MARCOS Approach with Dombi Aggregation Operators for Evaluating Indoor Sex Work Risk in …
P Majumder, A Das, P Kaliyaperumal, T Senapati… - 2024 - Elsevier
WITHDRAWN: An OPA-F-Based Single-Valued Neutrosophic Fuzzy MARCOS Approach with
Dombi Aggregation Operators for Evaluating Indoor Sex Work Risk in the Economy …
Dombi Aggregation Operators for Evaluating Indoor Sex Work Risk in the Economy …
PRC1-mediated epigenetic programming is required to generate the ovarian reserve
The ovarian reserve defines the female reproductive lifespan, which in humans spans
decades due to robust maintenance of meiotic arrest in oocytes residing in primordial …
decades due to robust maintenance of meiotic arrest in oocytes residing in primordial …
Epigenetic plasticity safeguards heterochromatin configuration in mammals
Heterochromatin is a key architectural feature of eukaryotic chromosomes critical for cell
type-specific gene expression and genome stability. In the mammalian nucleus …
type-specific gene expression and genome stability. In the mammalian nucleus …
[HTML][HTML] Epigenetic mechanisms governing female and male germline development in mammals
Background: DNA methylation (DNAme) and histone posttranslational modifications (PTMs)
play an integral role in the transcriptional regulation of specific sets of genes and …
play an integral role in the transcriptional regulation of specific sets of genes and …