Mitochondria, with their intricate networks of functions and information processing, are
pivotal in both health regulation and disease progression. Particularly, mitochondrial …

The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …

Like the organism they constitute, the cells also die in different ways. The death can be
predetermined, programmed, and cleanly executed, as in the case of apoptosis, or it can be …