Revisiting the neurovascular unit
S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
Neuroprotective effect of SGLT2 inhibitors
A Pawlos, M Broncel, E Woźniak, P Gorzelak-Pabiś - Molecules, 2021 - mdpi.com
Patients with diabetes are at higher risk of cardiovascular diseases and cognitive
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …
Single-cell dissection of the human brain vasculature
Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …
and in understanding neurodegeneration and drug delivery to the central nervous system …
Compilation of reported protein changes in the brain in Alzheimer's disease
Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life
A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …
however, whether they share pathophysiology is unclear and is the focus of our …
Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3
Protein S-nitros (yl) ation (SNO) is a posttranslational modification involved in diverse
processes in health and disease and can contribute to synaptic damage in Alzheimer's …
processes in health and disease and can contribute to synaptic damage in Alzheimer's …
Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease
YJ Sung, C Yang, J Norton, M Johnson… - Science translational …, 2023 - science.org
Proteomic studies for Alzheimer's disease (AD) are instrumental in identifying AD pathways
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …