Dynamic balance of pro‐and anti‐inflammatory signals controls disease and limits pathology
Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …
and this is especially true for infections by persistent pathogens. One mechanism that allows …
Insight into treatment of HIV infection from viral dynamics models
The odds of living a long and healthy life with HIV infection have dramatically improved with
the advent of combination antiretroviral therapy. Along with the early development and …
the advent of combination antiretroviral therapy. Along with the early development and …
Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys
EN Borducchi, C Cabral, KE Stephenson, J Liu… - Nature, 2016 - nature.com
The development of immunologic interventions that can target the viral reservoir in HIV-1-
infected individuals is a major goal of HIV-1 research,. However, little evidence exists that …
infected individuals is a major goal of HIV-1 research,. However, little evidence exists that …
Modeling the mechanics of viral kinetics under immune control during primary infection of HIV-1 with treatment in fractional order
In this paper, we propose and analyze a fractional order model of viral kinetics for primary
infection of HIV-1 in presence of immune control with treatment, as the classical model of …
infection of HIV-1 in presence of immune control with treatment, as the classical model of …
Dynamical demeanour of SARS-CoV-2 virus undergoing immune response mechanism in COVID-19 pandemic
COVID-19 is caused by the increase of SARS-CoV-2 viral load in the respiratory system.
Epithelial cells in the human lower respiratory tract are the major target area of the SARS …
Epithelial cells in the human lower respiratory tract are the major target area of the SARS …
Host‐pathogen kinetics during influenza infection and coinfection: insights from predictive modeling
AM Smith - Immunological reviews, 2018 - Wiley Online Library
Influenza virus infections are a leading cause of morbidity and mortality worldwide. This is
due in part to the continual emergence of new viral variants and to synergistic interactions …
due in part to the continual emergence of new viral variants and to synergistic interactions …
Stochastic models for virus and immune system dynamics
New stochastic models are developed for the dynamics of a viral infection and an immune
response during the early stages of infection. The stochastic models are derived based on …
response during the early stages of infection. The stochastic models are derived based on …
Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics
A Hailegiorgis, Y Ishida, N Collier… - PLOS Computational …, 2023 - journals.plos.org
Hepatitis B virus (HBV) infection kinetics in immunodeficient mice reconstituted with
humanized livers from inoculation to steady state is highly dynamic despite the absence of …
humanized livers from inoculation to steady state is highly dynamic despite the absence of …
Influenza virus infection model with density dependence supports biphasic viral decay
AP Smith, DJ Moquin, V Bernhauerova… - Frontiers in …, 2018 - frontiersin.org
Mathematical models that describe infection kinetics help elucidate the time scales,
effectiveness, and mechanisms underlying viral growth and infection resolution. For …
effectiveness, and mechanisms underlying viral growth and infection resolution. For …
The reproduction number and its probability distribution for stochastic viral dynamics
B Williams, J Carruthers, JJ Gillard… - Journal of the …, 2024 - royalsocietypublishing.org
We consider stochastic models of individual infected cells. The reproduction number, R, is
understood as a random variable representing the number of new cells infected by one …
understood as a random variable representing the number of new cells infected by one …