The scavenger receptor, class B type 1 (SR-B1), is a multiligand membrane receptor protein
that functions as a physiologically relevant high-density lipoprotein (HDL) receptor whose …

Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …

Signal transduction is initiated by complex protein–protein interactions between ligands,
receptors and kinases, to name only a few. It is now becoming clear that lipid micro …

Mammalian cell membranes are composed of a complex array of glycerophospholipids and
sphingolipids that vary in head-group and acyl-chain composition. In a given cell type …

Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …

Lipids, the basic components of the cell membrane, execute fundamental roles in almost all
the cell activities including cell-cell recognition, signalling transduction and energy supplies …

The main biological cause of oxysterols is the oxidation of cholesterol. They differ from
cholesterol by the presence of additional polar groups that are typically hydroxyl, keto …

The pathogenic event common to all forms of Alzheimer's disease is the abnormal
accumulation of the amyloid β-peptide (Aβ). Here we provide strong evidence that …

Secreted signaling proteins of the Hedgehog family organize spatial pattern during animal
development. Two integral membrane proteins have been identified with distinct roles in …