Microglia in retinal degeneration
K Rashid, I Akhtar-Schaefer, T Langmann - Frontiers in immunology, 2019 - frontiersin.org
The retina is a complex tissue with multiple cell layers that are highly ordered. Its
sophisticated structure makes it especially sensitive to external or internal perturbations that …
sophisticated structure makes it especially sensitive to external or internal perturbations that …
Mechanisms of photoreceptor death in retinitis pigmentosa
F Newton, R Megaw - Genes, 2020 - mdpi.com
Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …
[HTML][HTML] Glia–neuron interactions in the mammalian retina
The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …
and the interactions of glia with blood vessels. Three main types of glial cells are found in …
The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration
C Altmann, MHH Schmidt - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes mellitus, which appears in one
third of all diabetic patients and is a prominent cause of vision loss. First discovered as a …
third of all diabetic patients and is a prominent cause of vision loss. First discovered as a …
Microglia in the retina: roles in development, maturity, and disease
SM Silverman, WT Wong - Annual review of vision science, 2018 - annualreviews.org
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
retina. Recent evidence indicates that microglia play significant functional roles in the retina …
Retinal microglia: just bystander or target for therapy?
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
Retinal microglia–A key player in healthy and diseased retina
G Rathnasamy, WS Foulds, EA Ling, C Kaur - Progress in neurobiology, 2019 - Elsevier
Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …
Immune modulation by MANF promotes tissue repair and regenerative success in the retina
INTRODUCTION Regenerative therapies based on cell replacement hold promise for the
treatment of a range of age-related degenerative diseases but are limited by unfavorable …
treatment of a range of age-related degenerative diseases but are limited by unfavorable …
Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1
Although accumulated evidence supports the notion that mesenchymal stem cells (MSCs)
act in a paracrine manner, the mechanisms are still not fully understood. Recently, MSC …
act in a paracrine manner, the mechanisms are still not fully understood. Recently, MSC …
Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa
N Yoshida, Y Ikeda, S Notomi, K Ishikawa, Y Murakami… - Ophthalmology, 2013 - Elsevier
PURPOSE: To study the nature of inflammatory reaction in eyes of patients with retinitis
pigmentosa (RP) and its possible role in the pathogenesis of RP. DESIGN: Retrospective …
pigmentosa (RP) and its possible role in the pathogenesis of RP. DESIGN: Retrospective …