Microglia in retinal degeneration

K Rashid, I Akhtar-Schaefer, T Langmann - Frontiers in immunology, 2019 - frontiersin.org
The retina is a complex tissue with multiple cell layers that are highly ordered. Its
sophisticated structure makes it especially sensitive to external or internal perturbations that …

Mechanisms of photoreceptor death in retinitis pigmentosa

F Newton, R Megaw - Genes, 2020 - mdpi.com
Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

[HTML][HTML] Glia–neuron interactions in the mammalian retina

E Vecino, FD Rodriguez, N Ruzafa, X Pereiro… - Progress in retinal and …, 2016 - Elsevier
The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …

The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration

C Altmann, MHH Schmidt - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes mellitus, which appears in one
third of all diabetic patients and is a prominent cause of vision loss. First discovered as a …

Microglia in the retina: roles in development, maturity, and disease

SM Silverman, WT Wong - Annual review of vision science, 2018 - annualreviews.org
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Retinal microglia: just bystander or target for therapy?

M Karlstetter, R Scholz, M Rutar, WT Wong… - Progress in retinal and …, 2015 - Elsevier
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

Retinal microglia–A key player in healthy and diseased retina

G Rathnasamy, WS Foulds, EA Ling, C Kaur - Progress in neurobiology, 2019 - Elsevier
Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

Immune modulation by MANF promotes tissue repair and regenerative success in the retina

J Neves, J Zhu, P Sousa-Victor, M Konjikusic, R Riley… - Science, 2016 - science.org
INTRODUCTION Regenerative therapies based on cell replacement hold promise for the
treatment of a range of age-related degenerative diseases but are limited by unfavorable …

Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1

B Yu, H Shao, C Su, Y Jiang, X Chen, L Bai, Y Zhang… - Scientific reports, 2016 - nature.com
Although accumulated evidence supports the notion that mesenchymal stem cells (MSCs)
act in a paracrine manner, the mechanisms are still not fully understood. Recently, MSC …

Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa

N Yoshida, Y Ikeda, S Notomi, K Ishikawa, Y Murakami… - Ophthalmology, 2013 - Elsevier
PURPOSE: To study the nature of inflammatory reaction in eyes of patients with retinitis
pigmentosa (RP) and its possible role in the pathogenesis of RP. DESIGN: Retrospective …