Genomic imprinting affects a subset of genes in mammals and results in a monoallelic,
parental-specific expression pattern. Most of these genes are located in clusters that are …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

ABSTRACT A vast array of successive epigenetic modifications ensures the creation of a
healthy individual. Crucial epigenetic reprogramming events occur during germ cell …

A model based on DNA methylation is proposed to explain the initiation and maintenance of
mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell …

Normal mammalian development requires a maternal and paternal contribution, which is
attributed to imprinted genes, or genes that are expressed from a single parental allele …

Gene silencing is a negative feedback mechanism that regulates gene expression to define
cell fate and also regulates metabolism and gene expression throughout the life of an …

During X inactivation, mammalian female cells make the selection of one active and one
inactive X chromosome. X chromosome choice occurs randomly and results in **st …

Some difficulties with the classical model for the evolution of a genetically invert Y
chromosome are discussed. An alternative model is proposed, which is based on the …

▪ Abstract A handful of autosomal genes in the mammalian genome are inherited in a silent
state from one of the two parents, and in a fully active form from the other, thereby rendering …

Genomic imprinting is an epigenetic process leading to parental-specific expression of one
to two percent of mammalian genes that offers one of the best model systems for a molecular …