30 years of NF-κB: a blossoming of relevance to human pathobiology
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …
time, it has been found to have a broad role in gene induction in diverse cellular responses …
Signaling to NF-κB
The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …
decades. Over this period, considerable progress has been made in determining the …
The SYK tyrosine kinase: a crucial player in diverse biological functions
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …
NF-κB and the immune response
One of the primary physiological roles of nuclear factor-kappa B (NF-κB) is in the immune
system. In particular, NF-κB family members control the transcription of cytokines and …
system. In particular, NF-κB family members control the transcription of cytokines and …
CD28 and CTLA‐4 coreceptor expression and signal transduction
CE Rudd, A Taylor, H Schneider - Immunological reviews, 2009 - Wiley Online Library
T‐cell activation is mediated by antigen‐specific signals from the TCRζ/CD3 and CD4–CD8–
p56lck complexes in combination with additional co‐signals provided by coreceptors such …
p56lck complexes in combination with additional co‐signals provided by coreceptors such …
Essential function for the kinase TAK1 in innate and adaptive immune responses
S Sato, H Sanjo, K Takeda, J Ninomiya-Tsuji… - Nature …, 2005 - nature.com
Transforming growth factor-β–activated kinase 1 (TAK1) has been linked to interleukin 1
receptor and tumor necrosis factor receptor signaling. Here we generated mouse strains …
receptor and tumor necrosis factor receptor signaling. Here we generated mouse strains …
Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma
G Lenz, RE Davis, VN Ngo, L Lam, TC George… - Science, 2008 - science.org
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's
lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is …
lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is …
The follicular versus marginal zone B lymphocyte cell fate decision
S Pillai, A Cariappa - Nature Reviews Immunology, 2009 - nature.com
Bone marrow-derived B cells make an important cell fate choice to develop into either
follicular B cells or marginal zone B cells in the spleen, which depends on signalling through …
follicular B cells or marginal zone B cells in the spleen, which depends on signalling through …
Tumor necrosis factor receptor‐associated factor 6 (TRAF 6) regulation of development, function, and homeostasis of the immune system
MC Walsh, JE Lee, Y Choi - Immunological reviews, 2015 - Wiley Online Library
Tumor necrosis factor receptor (TNFR)‐associated factor 6 (TRAF 6) is an adapter protein
that mediates a wide array of protein–protein interactions via its TRAF domain and a RING …
that mediates a wide array of protein–protein interactions via its TRAF domain and a RING …
B cell antigen receptor signaling 101
JM Dal Porto, SB Gauld, KT Merrell, D Mills… - Molecular …, 2004 - Elsevier
All cells continually survey their environment and make decisions based on cues
encountered. This requires specific receptors that detect such cues, then transduce signals …
encountered. This requires specific receptors that detect such cues, then transduce signals …