ThT 101: a primer on the use of thioflavin T to investigate amyloid formation
K Gade Malmos, LM Blancas-Mejia, B Weber… - Amyloid, 2017 - Taylor & Francis
Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989. While
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …
[HTML][HTML] Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Although its
pathogenesis remains unclear, studies have indicated microglia-mediated …
pathogenesis remains unclear, studies have indicated microglia-mediated …
Subty** of circulating exosome-bound amyloid β reflects brain plaque deposition
Despite intense interests in develo** blood measurements of Alzheimer's disease (AD),
the progress has been confounded by limited sensitivity and poor correlation to brain …
the progress has been confounded by limited sensitivity and poor correlation to brain …
The hidden role of non-canonical amyloid β isoforms in Alzheimer's disease
Recent advances have placed the pro-inflammatory activity of amyloid β (Aβ) on microglia
cells as the focus of research on Alzheimer's Disease (AD). Researchers are confronted with …
cells as the focus of research on Alzheimer's Disease (AD). Researchers are confronted with …
Complete aggregation pathway of amyloid β (1-40) and (1-42) resolved on an atomically clean interface
To visualize amyloid β (Aβ) aggregates requires an uncontaminated and artifact-free
interface. This paper demonstrates the interface between graphene and pure water (verified …
interface. This paper demonstrates the interface between graphene and pure water (verified …
Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes—Activation and Age-Related Effects
In the central nervous system (CNS), microglia are innate immune mononuclear phagocytes
(CNS MPs) that can phagocytose infectious particles, apoptotic cells, neurons, and …
(CNS MPs) that can phagocytose infectious particles, apoptotic cells, neurons, and …
Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE
Mitochondrial DNA variants have previously associated with disease, but the underlying
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …
Optical nanosensor for intracellular and intracranial detection of amyloid-beta
Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer's disease (AD), but the
early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical …
early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical …
Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer's disease
Proteinaceous aggregation is a well-known observable in Alzheimer's disease (AD), but
failure and storage of lysosomal bodies within neurons is equally ubiquitous and actually …
failure and storage of lysosomal bodies within neurons is equally ubiquitous and actually …
Human cystatin C induces the disaggregation process of selected amyloid beta peptides: a structural and kinetic view
Neurodegenerative diseases, such as Alzheimer's disease (AD) and various types of
amyloidosis, are incurable; therefore, understanding the mechanisms of amyloid …
amyloidosis, are incurable; therefore, understanding the mechanisms of amyloid …