Enhancement of ketoprofen dissolution rate by the liquisolid technique: Optimization and in vitro and in vivo investigations

S Devi, S Kumar, V Verma, D Kaushik, R Verma… - Drug Delivery and …, 2022 - Springer
The objective of the current study is to evaluate the prospective of liquisolid formulation to
improve the dissolution rate of ketoprofen and thereby the bioavailability. Different batches …

Ketoprofen–FA Co-crystal: In Vitro and In Vivo Investigation for the Solubility Enhancement of Drug by Design of Expert

S Devi, A Kumar, A Kapoor, V Verma, S Yadav… - AAPS …, 2022 - Springer
The present piece of research work is framed for improving the solubility of ketoprofen by
forming co-crystal using fumaric acid as a coformer. Co-crystal of ketoprofen and fumaric …

Improved solubility and dissolution rate of ketoprofen by the formation of multicomponent crystals with tromethamine

L Fitriani, WA Firdaus, W Sidadang, H Rosaini… - Crystals, 2022 - mdpi.com
This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent
crystals with tromethamine. The multicomponent crystals (equimolar ratio) of ketoprofen and …

Co-crystallization: a green approach for the solubility enhancement of poorly soluble drugs

M Bhatia, S Devi - CrystEngComm, 2024 - pubs.rsc.org
Recently, the co-crystallization of pharmaceutical drugs is gaining consideration because it
is an environmentally friendly and potentially effective technique to improve the solubility …

Development of ketoprofen-p-aminobenzoic acid co-crystal: formulation, characterization, optimization, and evaluation

M Bhatia, A Kumar, V Verma, S Devi - Medicinal Chemistry Research, 2021 - Springer
In the present study, ketoprofen-p-aminobenzoic acid (KP-PABA) co-crystal was prepared, to
advance solubility and dissolution rate of drug, by solvent evaporation technique employing …

Enhancing Ketoprofen Solubility: A Strategic Approach Using Solid Dispersion and Response Surface Methodology

D Tripathi, DK Sharma, J Sahoo - Current …, 2024 - benthamdirect.com
Background In the pharmaceutical sciences, the solubility profile of therapeutic molecules is
crucial for identifying and formulating drugs and evaluating their quality across the drug …

Solid Dispersion Formulation Methods and Applications in Drug Delivery

N Sihag, K Bahmani, S Grewal, R Tanwar… - Current Physical …, 2024 - benthamdirect.com
About 44% of the active medicinal components in all previously disclosed chemical units are
hydrophobic and do not extend shop because of their limited water solubility. One of the …

Development of hesperidin solid dispersion for improved solubility and dissolution using mannitol and PVP K30 as carriers

P Swarup, GP Agrawal - Journal of Applied Pharmaceutical …, 2024 - japtronline.com
Background: Despite its six-hour half-life, Hesperidin, a bioflavonoid with therapeutic
benefits, has low water solubility and bioavailability. This limits treatment. This study …

[PDF][PDF] A study on solubility enhancement of etravirine by crystal engineering method

S Bhattacharyya, H Adhikari, D Regmi… - Indian J Pharm …, 2022 - academia.edu
Etravirine, an antiretroviral agent, used in the treatment of human immunodeficiency virus
belongs to biopharmaceutical classification system classification IV. The reported solubility …

Formulation and optimization: Liquisolid of domperidone for solubility enhancement

M BHATIA, R Geeta, K BAHMANI… - ACTA Pharmaceutica … - actapharmsci.com
In the present study, liquisolid formulations of domperidone were prepared using Tween 80,
microcrystalline cellulose, Aerosil 200 as solvent, carrier, and coating material, respectively …