Ribosome biogenesis in disease: new players and therapeutic targets
L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - … and Targeted Therapy, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …
biogenesis is the process that generates ribosomes and plays an essential role in cell …
Sarcopenia: etiology, nutritional approaches, and miRNAs
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …
Normalization strategies differently affect circulating miRNA profile associated with the training status
M Faraldi, M Gomarasca, V Sansoni, S Perego… - Scientific Reports, 2019 - nature.com
MicroRNAs are fine regulators of the whole-body adaptive response but their use as
biomarkers is limited by the lack of standardized pre-and post-analytical procedures. This …
biomarkers is limited by the lack of standardized pre-and post-analytical procedures. This …
Mitochondrial dysfunction in airways and quadriceps muscle of patients with chronic obstructive pulmonary disease
Background Mitochondrial damage and dysfunction have been reported in airway and
quadriceps muscle cells of patients with chronic obstructive pulmonary disease (COPD). We …
quadriceps muscle cells of patients with chronic obstructive pulmonary disease (COPD). We …
Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading
Background Translational capacity (ie ribosomal mass) is a key determinant of protein
synthesis and has been associated with skeletal muscle hypertrophy. The role of …
synthesis and has been associated with skeletal muscle hypertrophy. The role of …
H19X-encoded miR-424 (322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
Abstract miR-424 (322)/-503 are mammal-specific members of the extended miR-15/107
microRNA family. They form a co-expression network with the imprinted lncRNA H19 in …
microRNA family. They form a co-expression network with the imprinted lncRNA H19 in …
Circulating miR‐203 derived from metastatic tissues promotes myopenia in colorectal cancer patients
Background Sarcopenia frequently occurs in metastatic cancer patients. Emerging evidence
has revealed that various secretory products from metastatic tumours can influence host …
has revealed that various secretory products from metastatic tumours can influence host …
Shared and divergent epigenetic mechanisms in cachexia and sarcopenia
L Yedigaryan, M Gatti, V Marini, T Maraldi… - Cells, 2022 - mdpi.com
Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major
causes of mortality and disability. Cachexia represents a complex multi-organ syndrome …
causes of mortality and disability. Cachexia represents a complex multi-organ syndrome …
Regulation of microRNAs in satellite cell renewal, muscle function, sarcopenia and the role of exercise
S Fochi, G Giuriato, T De Simone… - International journal of …, 2020 - mdpi.com
Sarcopenia refers to a condition of progressive loss of skeletal muscle mass and function
associated with a higher risk of falls and fractures in older adults. Musculoskeletal aging …
associated with a higher risk of falls and fractures in older adults. Musculoskeletal aging …
MicroRNAs in obesity, sarcopenia, and commonalities for sarcopenic obesity: a systematic review
L Dowling, A Duseja, T Vilaca, JS Walsh… - Journal of Cachexia …, 2022 - Wiley Online Library
Sarcopenic obesity is a distinct condition of sarcopenia in the context of obesity, with the
cumulative health risks of both phenotypes. Differential expression of microRNAs (miRNAs) …
cumulative health risks of both phenotypes. Differential expression of microRNAs (miRNAs) …