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Ionotropic GABA and glutamate receptor mutations and human neurologic diseases
The advent of whole exome/genome sequencing and the technology-driven reduction in the
cost of next-generation sequencing as well as the introduction of diagnostic-targeted …
cost of next-generation sequencing as well as the introduction of diagnostic-targeted …
[HTML][HTML] GABA actions and ionic plasticity in epilepsy
K Kaila, E Ruusuvuori, P Seja, J Voipio… - Current opinion in …, 2014 - Elsevier
Highlights•Ionic plasticity of GABA signaling relies on short-term and long term changes in E
GABA.•Cl− transport and carboanhydrases play a key role in ionic plasticity and …
GABA.•Cl− transport and carboanhydrases play a key role in ionic plasticity and …
GABAA receptors and plasticity of inhibitory neurotransmission in the central nervous system
JM Fritschy, P Panzanelli - European Journal of Neuroscience, 2014 - Wiley Online Library
GABAA receptors (GABAAR s) are ligand‐gated Cl− channels that mediate most of the fast
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …
Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?
A Demirtas-Tatlidede, AM Vahabzadeh-Hagh… - …, 2013 - Elsevier
Cognitive impairment is a core symptom of many neuropsychiatric diseases and a key
contributor to the patient's quality of life. However, an effective therapeutic strategy has yet to …
contributor to the patient's quality of life. However, an effective therapeutic strategy has yet to …
Neurosteroids, stress and depression: potential therapeutic opportunities
CF Zorumski, SM Paul, Y Izumi, DF Covey… - Neuroscience & …, 2013 - Elsevier
Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …
The role of the central amygdala in alcohol dependence
Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug-
seeking and drug-taking, loss of control in limiting intake, and the emergence of a …
seeking and drug-taking, loss of control in limiting intake, and the emergence of a …
Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target
Ischaemic stroke is the leading cause of severe long-term disability yet lacks drug therapies
that promote the repair phase of recovery. This repair phase of stroke occurs days to months …
that promote the repair phase of recovery. This repair phase of stroke occurs days to months …
Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …
Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology
D Castellano, RD Shepard, W Lu - Frontiers in neuroscience, 2021 - frontiersin.org
Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
A functional role for both γ‐aminobutyric acid (GABA) transporter‐1 and GABA transporter‐3 in the modulation of extracellular GABA and GABAergic tonic …
F Kersanté, SCS Rowley, I Pavlov… - The Journal of …, 2013 - Wiley Online Library
Key points• The extracellular concentration of the neurotransmitter γ‐aminobutyric acid
(GABA) is critical in determining GABAA receptor‐mediated tonic conductance in the …
(GABA) is critical in determining GABAA receptor‐mediated tonic conductance in the …