There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

Synaptic activity initiates biochemical processes that have various outcomes, including the
formation of memories, increases in neuronal survival and the development of chronic pain …

Because of the association between aberrant nuclear structure and tumour grade, nuclear
morphology is an indispensible criterion in the current pathological assessment of cancer …

Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise
from defects in experience-dependent synapse maturation. RTT is caused by mutations in …

In this Perspective, we synthesize past and present observations in the field of epigenetics to
propose a model in which the epigenome can modulate cellular plasticity in development …

Unraveling the fine structure of the brain is important to provide a better understanding of its
normal and abnormal functioning. Application of high-resolution electron microscopic …

Expansion microscopy (ExM) allows scalable imaging of preserved 3D biological specimens
with nanoscale resolution on fast diffraction-limited microscopes. Here, we explore the utility …

The development and function of neurons require the regulated expression of large
numbers of very specific gene sets. Epigenetic modifications of both DNA and histone …

Over the past two decades, the biomechanical properties of cells have emerged as key
players in a broad range of cellular functions, including migration, proliferation, and …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …