Raman spectroscopy for chemical biology research
In chemical biology research, various fluorescent probes have been developed and used to
visualize target proteins or molecules in living cells and tissues, yet there are limitations to …
visualize target proteins or molecules in living cells and tissues, yet there are limitations to …
From genotype to phenotype: Raman spectroscopy and machine learning for label-free single-cell analysis
Y Zhang, K Chang, B Ogunlade, L Herndon… - ACS …, 2024 - ACS Publications
Raman spectroscopy has made significant progress in biosensing and clinical research.
Here, we describe how surface-enhanced Raman spectroscopy (SERS) assisted with …
Here, we describe how surface-enhanced Raman spectroscopy (SERS) assisted with …
Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity
Almost all biomedical research to date has relied upon mean measurements from cell
populations, however it is well established that what it is observed at this macroscopic level …
populations, however it is well established that what it is observed at this macroscopic level …
Single-cell map** of lipid metabolites using an infrared probe in human-derived model systems
Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …
Quantitative chemometric phenoty** of three-dimensional liver organoids by Raman spectral imaging
Confocal Raman spectral imaging (RSI) enables high-content, label-free visualization of a
wide range of molecules in biological specimens without sample preparation. However …
wide range of molecules in biological specimens without sample preparation. However …
Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids
Organoids formed from human induced pluripotent stem cells (hiPSCs) could be a limitless
source of functional tissue for transplantations in many organs. Unfortunately, fine-tuning …
source of functional tissue for transplantations in many organs. Unfortunately, fine-tuning …
High-speed diagnosis of bacterial pathogens at the single cell level by Raman microspectroscopy with machine learning filters and Denoising autoencoders
J Xu, X Yi, G **, D Peng, G Fan, X Xu… - ACS Chemical …, 2022 - ACS Publications
Accurate and rapid identification of infectious bacteria is important in medicine. Raman
microspectroscopy holds great promise in performing label-free identification at the single …
microspectroscopy holds great promise in performing label-free identification at the single …
Raman spectroscopy and machine learning for the classification of esophageal squamous carcinoma
W Huang, Q Shang, X **ao, H Zhang, Y Gu… - … Acta Part A: Molecular …, 2022 - Elsevier
Early diagnosis of esophageal squamous cell carcinoma (ESCC), a common malignant
tumor with a low overall survival rate due to metastasis and recurrence, is critical for effective …
tumor with a low overall survival rate due to metastasis and recurrence, is critical for effective …
Diagnostics and therapy assessment using label-free Raman imaging
Raman microspectroscopy is an emerging analytical tool that can monitor the biochemical
composition of biological or biomedical specimens, including proteins, cells, and tissues, as …
composition of biological or biomedical specimens, including proteins, cells, and tissues, as …
[HTML][HTML] Increased connectivity of hiPSC-derived neural networks in multiphase granular hydrogel scaffolds
CC Hsu, JH George, S Waller, C Besnard, DA Nagel… - Bioactive Materials, 2022 - Elsevier
To reflect human development, it is critical to create a substrate that can support long-term
cell survival, differentiation, and maturation. Hydrogels are promising materials for 3D …
cell survival, differentiation, and maturation. Hydrogels are promising materials for 3D …