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Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Biomarker of neuroinflammation in Parkinson's disease
Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria
Abstract Tunnelling Nanotubes (TNTs) facilitate contact-mediated intercellular
communication over long distances. Material transfer via TNTs can range from ions and …
communication over long distances. Material transfer via TNTs can range from ions and …
Parkinson disease and the immune system—associations, mechanisms and therapeutics
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
Targeting microglial α-synuclein/TLRs/NF-kappaB/NLRP3 inflammasome axis in Parkinson's disease
According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …
release of pro-inflammatory cytokines play important roles in the pathogenesis and …
Immunological dimensions of neuroinflammation and microglial activation: Exploring innovative immunomodulatory approaches to mitigate neuroinflammatory …
The increasing life expectancy has led to a higher incidence of age-related
neurodegenerative conditions. Within this framework, neuroinflammation emerges as a …
neurodegenerative conditions. Within this framework, neuroinflammation emerges as a …
[HTML][HTML] Microglia and astrocyte dysfunction in parkinson's disease
While glia are essential for regulating the homeostasis in the normal brain, their dysfunction
contributes to neurodegeneration in many brain diseases, including Parkinson's disease …
contributes to neurodegeneration in many brain diseases, including Parkinson's disease …
Periphery and brain, innate and adaptive immunity in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …
central role in the death and dysfunction of neurons, both, in central, as well as in the …
Inflammasome assembly in neurodegenerative diseases
Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …
selectively vulnerable neuronal populations, often associated with the accumulation of …