The effects of statins, ezetimibe, PCSK9-inhibitors, inclisiran, and icosapent ethyl on platelet function

A Di Costanzo, C Indolfi, S Sorrentino… - International Journal of …, 2023 - mdpi.com
This review aims to examine the complex interaction between dyslipidemia, platelet function,
and related drug treatments. In particular, the manuscript provides an overview of the effects …

Platelets as Potential Non-Traditional Cardiovascular Risk Factor—Analysis Performed in Healthy Donors

P Szymańska, B Luzak, P Siarkiewicz… - International Journal of …, 2023 - mdpi.com
Abnormal lipid profile, increased glucose level, and elevated body weight are traditional
cardiometabolic risk factors; however, the role of platelets in the development of …

Association of platelet-monocyte ratio with dyslipidemia in Saudi Arabia: a large, population-based study

MA Alfhili, GA Alotaibi, M Alfaifi, Y Almoghrabi… - Life, 2023 - mdpi.com
Background: Abnormal lipid metabolism predisposes to cardiovascular disease. However,
dyslipidemia is often asymptomatic leading to its underdiagnosis. Therefore, it is of utmost …

Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death

MA Alfhili, J Alsughayyir - Xenobiotica, 2023 - Taylor & Francis
Deguelin (DGN), a retinoid isolated from many plants, exhibits a potent anticancer activity
against a wide spectrum of tumour cells. There is a dearth of evidence, however, regarding …

Bufalin reprograms erythrocyte lifespan through p38 MAPK and Rac1 GTPase

MA Alfhili, J Alsughayyir - Toxicon, 2024 - Elsevier
Ample evidence indicates that bufalin (BFN), a cardiotonic steroid in Bufo toad toxin,
possesses a potent anticancer activity mainly by stimulating apoptosis in cancer cells …

Single nucleotide polymorphism rs7961894, platelet morphological parameters and lipid profile in children with type 1 diabetes: a potential relationship

MA El-Hawy, S Abdelsattar, HM Bedair… - European Journal of …, 2024 - Springer
Increased cardiovascular risk has been associated with certain platelet morphological
parameters, and several single nucleotide polymorphisms (SNPs) have been reported to be …

Platelet‐associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity

J Duran‐Bertran, EC Rusu… - European Journal of …, 2024 - Wiley Online Library
Background There is a lack of noninvasive diagnostic methods for nonalcoholic
steatohepatitis (NASH), the severe condition of metabolic dysfunction‐associated steatotic …

Cardiometabolic risk factor burden associates with an immature platelet profile

CE Hamo, M Muller, E Rosenfeld, Y **a, A Akinlonu… - Platelets, 2025 - Taylor & Francis
Cardiometabolic risk factors, obesity, diabetes and hyperlipidemia contribute to
cardiovascular disease (CVD). While platelets are involved in CVD pathogenesis, the …

Thrombotic Disease in Hemophilic Patients: Is This a Paradox in a State of Hypocoagulability?

OV Badulescu, MC Badescu, IB Bojan, M Vladeanu… - Diagnostics, 2024 - mdpi.com
Hemophilia patients have a deficiency in or dysfunction of clotting factors, which can lead to
a bleeding tendency. However, paradoxically, some hemophilia patients may also be at an …

[HTML][HTML] Emerging Clinical Problem of Resistance to Antiplatelet Therapy in Primary Prevention and Treatment of Cardiovascular Events in People Living with HIV …

G Ogweno, E Kimathi - 2023 - intechopen.com
Despite the extensive use of combined antiretroviral therapy (cART) for effective human
immunodeficiency viral (HIV) suppression, people living with HIV have an increased risk of …