Fully implantable wireless systems for the recording and modulation of neural circuits that do
not require physical tethers or batteries allow for studies that demand the use of …

Microglia are phagocytic cells that infiltrate the brain during development and have a role in
the elimination of synapses during brain maturation. Changes in microglial morphology and …

Sleep is a vital part of our lives as it is required to maintain health and optimal cognition. In
humans, sex differences are relatively well-established for many sleep phenotypes …

Theta oscillations (4–12 Hz) are thought to provide a common temporal reference for the
exchange of information among distant brain networks. On the other hand, faster gamma …

Slow brain oscillations are usually coherent over long distances and thought to link
distributed cell assemblies. In mice, theta (5–10 Hz) stands as one of the most studied slow …

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic
encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we …

It has been suggested that neuronal hyperexcitability contributes to Alzheimer's disease
(AD), so we asked how hyperexcitability develops in a common mouse model of β-amyloid …

Amyloid precursor protein (APP) is critically involved in the pathophysiology of Alzheimer's
disease, but its physiological functions remain elusive. Importantly, APP knockout (APP-KO) …

Background Wide-field calcium imaging (WFCI) allows for monitoring of cortex-wide neural
dynamics in mice. When applied to the study of sleep, WFCI data are manually scored into …

Nasal breathing generates a rhythmic signal which entrains cortical network oscillations in
widespread brain regions on a cycle-to-cycle time scale. It is unknown, however, how …