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Mendelian randomization: concepts and scope
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Meta‐analysis and Mendelian randomization: a review
Mendelian randomization (MR) uses genetic variants as instrumental variables to infer
whether a risk factor causally affects a health outcome. Meta‐analysis has been used …
whether a risk factor causally affects a health outcome. Meta‐analysis has been used …
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …
modifiable exposures on health outcomes, but the published evidence is often hampered by …
Guidelines for performing Mendelian randomization investigations: update for summer 2023
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
Anthropometric and adiposity indicators and risk of type 2 diabetes: systematic review and dose-response meta-analysis of cohort studies
Objective To present a comprehensive review of the association between measures of body
weight, waist, and fat, and different ratios of these measures, and the risk of type 2 diabetes …
weight, waist, and fat, and different ratios of these measures, and the risk of type 2 diabetes …
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on
the exposure in Mendelian randomization (MR). Violation of the 'no horizontal …
the exposure in Mendelian randomization (MR). Violation of the 'no horizontal …
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …
causal relations between potentially modifiable risk factors and health outcomes in …
Evaluating the potential role of pleiotropy in Mendelian randomization studies
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …
widespread in the human genome. If pleiotropy arises because the single nucleotide …
Risk factors for type 2 diabetes mellitus: an exposure-wide umbrella review of meta-analyses
Background Type 2 diabetes mellitus (T2DM) is a global epidemic associated with
increased health expenditure, and low quality of life. Many non-genetic risk factors have …
increased health expenditure, and low quality of life. Many non-genetic risk factors have …
Interpreting findings from Mendelian randomization using the MR-Egger method
Abstract Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …