Abstract Purpose of Review Skeletal muscle and bone are connected anatomically and
physiologically, and play a crucial role in human locomotion and metabolism. Historically …

Abstract Additive manufacturing (AM)(= 3D printing) and rational design techniques have
enabled development of meta-biomaterials with unprecedented combinations of …

This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts
and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside …

Wnt signaling plays a central regulatory role across a remarkably diverse range of functions
during embryonic development, including those involved in the formation of bone and …

Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause
of most chronic diseases. The initial third of the article considers: activity and prevention …

Bone tissue engineering utilizes three critical elements–cells, scaffolds, and bioactive factors–
to recapitulate the bone tissue microenvironment, inducing the formation of new bone …

It is a big challenge to design a biomimetic physical microenvironment with greater similarity
to in vivo tissue to observe real cell behaviors. We established a novel cell culture platform …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Stem cells hold great promise for widespread biomedical applications, for which stem cell
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …