The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …

Proteins are involved in many biological processes. Misfolded, truncated, or mutated
proteins as well as over-or underexpressed proteins have been implicated in many …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Most cellular processes are carried out by multiprotein complexes. The identification and
analysis of their components provides insight into how the ensemble of expressed proteins …

A typical protein kinase must recognize between one and a few hundred bona fide
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …

Protein kinase CK2 ('casein kinase II') has traditionally been classified as a messenger-
independent protein serine/threonine kinase that is typically found in tetrameric complexes …

The emergence of proteomics, the large-scale analysis of proteins, has been inspired by the
realization that the final product of a gene is inherently more complex and closer to function …

To facilitate studies of the yeast proteome, we cloned 5800 open reading frames and
overexpressed and purified their corresponding proteins. The proteins were printed onto …

Abstract In plants, numerous Ca2+-stimulated protein kinase activities occur through calcium-
dependent protein kinases (CDPKs). These novel calcium sensors are likely to be crucial …

Diagnosis and monitoring of complex diseases such as cancer require quantitative detection
of multiple proteins. Recent work has shown that when specific biomolecular binding occurs …