In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T
cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three …

Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …

Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …

There is a dramatic remodeling of the T cell compartment during aging. The most notorious
changes are the reduction of the naive T cell pool and the accumulation of memory-like T …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease that is estimated to
affect 35 million people worldwide and is characterized by lymphocytic infiltration, elevated …

The two major subsets of peripheral T cells are classically divided into the CD4+ T helper
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …

There are several autoimmune and rheumatic diseases affecting different organs of the
human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly …

Objective B cells are important in the pathogenesis of primary Sjögren's syndrome (pSS).
Patients positive for Sjögren's syndrome antigen A/Sjögren syndrome antigen B (SSA/SSB) …

Sjögren's disease (SjD) is an autoimmune disorder characterized by progressive salivary
and lacrimal gland dysfunction, inflammation, and destruction, as well as extraglandular …