Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Post-translational modifications (PTMs) occur during or after protein biosynthesis and
increase the functional diversity of proteome. They comprise phosphorylation, acetylation …

Cellular carbohydrates or glycans are critical mediators of biological function. Their
remarkably diverse structures and varied activities present exciting opportunities for …

Prostate cancer is the most common cancer in men and it is estimated that over 350,000
men worldwide die of prostate cancer every year. There remains an unmet clinical need to …

The dynamic change of cell-surface glycans is involved in diverse biological and
pathological events such as oncogenesis and metastasis. Despite tremendous efforts, it …

The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases
catalyze long-chain S-acylation at cysteine residues across an extensive network of …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Modified biopolymers that are based on prebiotics have been found to significantly
contribute to immunomodulatory events. In recent years, there has been a growing use of …

Cell membranes are key interfaces where materials engineering meets biology. Traditionally
regarded as just the location of receptors regulating the uptake of molecules, we now know …