Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated.
Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy …

Potential roles for lactate in the energetics of brain activation have changed radically during
the past three decades, shifting from waste product to supplemental fuel and signaling …

With the recognition of the central role of mitochondria in apoptosis, there is a need to
develop specific tools to manipulate mitochondrial function within cells. Here we report on …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

It is now clear that mitochondria are an important target for oxidative stress in a broad range
of pathologies, including cardiovascular disease, diabetes, neurodegeneration, and cancer …

Rhodamine 123 (RH-123) was used to monitor the membrane potential of mitochondria
isolated from rat liver. Mitochondrial energization induces quenching of RH-123 …

The contribution of mitochondria to the manifestation of disease is ascribed largely to the
production of reactive oxygen species (ROS), which are obligatory by-products of …

The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity.
Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express …

2.2. 2. Changes in intracellular ion concentrations 3. Energy parameters and changes
therein during increased activity, hypoglycemia and hypoxia/ischemia L 1. Alterations in …

In the past few years it has become apparent that mitochondria have an essential role in the
life and death of neuronal and non-neuronal cells. The central mitochondrial bioenergetic …