The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid
metabolism and many of these lipid genes are highly expressed in glial cells. However, the …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …

Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Alzheimer's disease (AD) is a complex, progressive primary neurodegenerative disease.
Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) …