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[HTML][HTML] An engineered CRISPR-Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells
Tracing the lineage history of cells is key to answering diverse and fundamental questions in
biology. Coupling of cell ancestry information with other molecular readouts represents an …
biology. Coupling of cell ancestry information with other molecular readouts represents an …
Diversity in biology: definitions, quantification and models
Diversity indices are useful single-number metrics for characterizing a complex distribution
of a set of attributes across a population of interest. The utility of these different metrics or …
of a set of attributes across a population of interest. The utility of these different metrics or …
Determining sequencing depth in a single-cell RNA-seq experiment
An underlying question for virtually all single-cell RNA sequencing experiments is how to
allocate the limited sequencing budget: deep sequencing of a few cells or shallow …
allocate the limited sequencing budget: deep sequencing of a few cells or shallow …
Classification and computation of extreme events in turbulent combustion
In the design of practical combustion systems, ensuring safety and reliability is an important
requirement. For instance, reliably avoiding lean blowout, flame flashback or inlet unstart is …
requirement. For instance, reliably avoiding lean blowout, flame flashback or inlet unstart is …
Estimating the unseen: improved estimators for entropy and other properties
We show that a class of statistical properties of distributions, which includes such practically
relevant properties as entropy, the number of distinct elements, and distance metrics …
relevant properties as entropy, the number of distinct elements, and distance metrics …
Chebyshev polynomials, moment matching, and optimal estimation of the unseen
We consider the problem of estimating the support size of a discrete distribution whose
minimum nonzero mass is at least 1 k. Under the independent sampling model, we show …
minimum nonzero mass is at least 1 k. Under the independent sampling model, we show …
Minimax Estimation of the Distance
We consider the problem of estimating the L 1 distance between two discrete probability
measures P and Q from empirical data in a nonasymptotic and large alphabet setting. When …
measures P and Q from empirical data in a nonasymptotic and large alphabet setting. When …
Maximum likelihood estimation of functionals of discrete distributions
We consider the problem of estimating functionals of discrete distributions, and focus on a
tight (up to universal multiplicative constants for each specific functional) nonasymptotic …
tight (up to universal multiplicative constants for each specific functional) nonasymptotic …
Genome-wide detection of DNA double-strand breaks by in-suspension BLISS
Abstract sBLISS (in-suspension breaks labeling in situ and sequencing) is a versatile and
widely applicable method for identification of endogenous and induced DNA double-strand …
widely applicable method for identification of endogenous and induced DNA double-strand …
Minimax estimation of divergences between discrete distributions
We study the minimax estimation of α-divergences between discrete distributions for integer
α≥ 1, which include the Kullback-Leibler divergence and the χ 2-divergences as special …
α≥ 1, which include the Kullback-Leibler divergence and the χ 2-divergences as special …