Hallmarks of cancer stemness

JJ Loh, S Ma - Cell Stem Cell, 2024 - cell.com
Cancer stemness is recognized as a key component of tumor development. Previously
coined" cancer stem cells"(CSCs) and believed to be a rare population with rigid …

Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

A Elmusrati, J Wang, CY Wang - International journal of oral science, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

[HTML][HTML] CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

C Wang, Y Li, L Jia, J koo Kim, J Li, P Deng, W Zhang… - Cell stem cell, 2021 - cell.com
Immunosurveillance is a critical mechanism guarding against tumor development and
progression. Checkpoint inhibitors have shown significant success in cancer treatment, but …

Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment

LTH Phi, IN Sari, YG Yang, SH Lee, N Jun… - Stem cells …, 2018 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression

J Chen, K Li, J Chen, X Wang, R Ling… - Cancer …, 2022 - Wiley Online Library
Background Cancer cells selectively promote the translation of oncogenic transcripts to
stimulate cancer progression. Although growing evidence has revealed that tRNA …

Targeting Notch in oncology: the path forward

S Majumder, JS Crabtree, TE Golde… - Nature Reviews Drug …, 2021 - nature.com
Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

A physiologically responsive nanocomposite hydrogel for treatment of head and neck squamous cell carcinoma via proteolysis‐targeting chimeras enhanced …

Y Wu, X Chang, G Yang, L Chen, Q Wu… - Advanced …, 2023 - Wiley Online Library
Although immunotherapy has revolutionized oncotherapy, only≈ 15% of head and neck
squamous cell carcinoma (HNSCC) patients benefit from the current therapies. An …

Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma

J Dong, J Li, Y Li, Z Ma, Y Yu, CY Wang - Nature communications, 2021 - nature.com
Cancer stem cells (CSCs) play a critical role in invasive growth and metastasis of human
head and neck squamous cell carcinoma (HNSCC). Although significant progress has been …

circFAT1 promotes cancer stemness and immune evasion by promoting STAT3 activation

L Jia, Y Wang, CY Wang - Advanced Science, 2021 - Wiley Online Library
Cancer stemness and immune evasion are closely associated, and play critical roles in
tumor development and resistance to immunotherapy. However, little is known about the …

Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340

X Jian, H He, J Zhu, Q Zhang, Z Zheng, X Liang… - Molecular cancer, 2020 - Springer
Background Accumulating evidence indicates that circular RNAs (circRNAs) act as
microRNA (miRNA) sponges to directly inhibit specific miRNAs and alter their ability to …