Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

This Review summarizes the advancements in Pd-catalyzed C (sp3)–H activation via
various redox manifolds, including Pd (0)/Pd (II), Pd (II)/Pd (IV), and Pd (II)/Pd (0). While few …

The functionalization of C (sp3)− H bonds streamlines chemical synthesis by allowing the
use of simple molecules and providing novel synthetic disconnections. Intensive recent …

The development of methods for the functionalization of otherwise inert C–H bonds is one of
the major foci in molecular syntheses. Recent advances have significantly improved the …

Cyclic organic molecules are common among natural products and pharmaceuticals,. In fact,
the overwhelming majority of small-molecule pharmaceuticals contain at least one ring …

Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

A novel and efficient visible-light-induced C (sp2)–H/N–H cross-dehydrogenative coupling
(CDC)-amination with both primary and secondary aliphatic amines at room temperature in …

Methods that enable the practical and selective functionalization of traditionally unreactive
aliphatic C–H bonds have synthetic applications in fields ranging from drug discovery to …