Neutrophils are the most abundant innate immune cell with critical anti-microbial functions.
Since the discovery of granulocytes at the end of the nineteenth century, the cells have been …

Tumor microenvironment has a major role in cancer progression and resistance to
treatment. The bone marrow (BM) is a dynamic network of growth factors, cytokines and …

Bone marrow stroma contains a unique cell population, referred to as marrow stromal cells
(MSCs), capable of differentiating along multiple mesenchymal cell lineages. A standard …

Neurons arise in the adult forebrain subventricular zone (SVZ) from Type B neural stem cells
(NSCs), raising considerable interest in the molecules that maintain this life-long neurogenic …

We have explored the functional implications of inducible α4 integrin deletion during adult
hematopoiesis by generating a conditional-knockout mouse model, and we show that α4 …

The classical definition of adult tissue stem cells (TSC) is fundamentally based on a
functional perspective. A TSC is an undifferentiated cell, capable of proliferation, self …

Mesenchymal stem cells (MSCs) have been isolated based on the ability of adherence to
plastic surfaces. The potential of these cells to differentiate along multiple lineages is the key …

Cytokine-mobilized peripheral blood hematopoietic stem cells (MPB HSC) are widely used
for transplantation in the treatment of malignancies, but the mechanism of HSC mobilization …

Uncovering the molecular mechanisms governing the exit of stem/progenitor cells from bone
marrow to peripheral blood at steady state or after their enforced migration has been an …

Although a large body of data on mobilization have yielded valuable clues, the mechanism
(s) dictating egress of stem/progenitor cells during baseline hematopoiesis and after their …