Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …

Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …