The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2) is a transcription
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …

Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …

Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

More than 20 years after its discovery, our understanding of target of rapamycin (TOR)
signalling continues to grow. Recent global'omics' studies have revealed physiological roles …

Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma
(LUAD) are associated with aggressive tumor growth, resistance to available therapies, and …

Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …