Blood-based biomarkers in Alzheimer's disease–moving towards a new era of diagnostics

B Arslan, H Zetterberg, NJ Ashton - Clinical Chemistry and …, 2024 - degruyter.com
Abstract Alzheimer's disease (AD), a primary cause of dementia globally, is traditionally
diagnosed via cerebrospinal fluid (CSF) measures and positron emission tomography …

Diagnostic performance of plasma pTau217, pTau181, Aβ1-42 and Aβ1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease

J Arranz, N Zhu, S Rubio-Guerra… - Alzheimer's Research & …, 2024 - Springer
Background Recently developed blood markers for Alzheimer's disease (AD) detection have
high accuracy but usually require ultra-sensitive analytic tools not commonly available in …

[HTML][HTML] Blood-Based Biomarkers in Alzheimer's Disease: Advancing Non-Invasive Diagnostics and Prognostics

M Dhauria, R Mondal, S Deb, G Shome… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD), the most prevalent form of dementia, is expected to rise
dramatically in incidence due to the global population aging. Traditional diagnostic …

Clinical evaluation of a novel plasma pTau217 electrochemiluminescence immunoassay in Alzheimer's disease

P Kivisäkk, HA Fatima, DS Cahoon, B Otieno… - Scientific Reports, 2024 - nature.com
A growing literature suggests that plasma levels of tau phosphorylated at amino acid 217
(pTau217) performs similarly to cerebrospinal fluid (CSF) biomarkers and PET imaging to …

Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy individuals

WS Brum, NJ Ashton, J Simrén… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Blood biomarkers have proven useful in Alzheimer's disease (AD)
research. However, little is known about their biological variation (BV), which improves the …

Plasma p‐tau217, p‐tau181, and NfL as early indicators of dementia risk in a community cohort: the Shanghai Aging Study

Z **ao, W Wu, X Ma, J Wu, X Liang… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Blood biomarkers showed values for predicting future cognitive
impairment. Evidence from the community‐based cohort was limited only in high‐income …

Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment

S Lehmann, S Schraen-Maschke, JS Vidal… - Journal of Neurology …, 2024 - jnnp.bmj.com
Background Among plasma biomarkers for Alzheimer's disease (AD), pTau181 and
pTau217 are the most promising. However, transition from research to routine clinical use …

Plasma pTau181 Predicts Clinical Progression in a Phase 2 Randomized Controlled Trial of the 11β-HSD1 Inhibitor Xanamem® for Mild Alzheimer's Disease

J Taylor, M Jaros, C Chen… - Journal of Alzheimer's …, 2024 - journals.sagepub.com
Background: Blood biomarkers are proposed as a diagnostic alternative to amyloid PET or
cerebrospinal fluid (CSF) analyses for the diagnosis of Alzheimer's disease (AD). Relatively …

Reactions of clinical neuropsychologists to the Alzheimer's Association workgroup's draft diagnostic and staging criteria for Alzheimer's disease

AM Kiselica, KJ Atkins, SD Han… - Journal of …, 2024 - journals.sagepub.com
Background An Alzheimer's Association (AA) workgroup published criteria for the diagnosis
and staging of Alzheimer's disease (AD). To date, there have not been empirical …

Plasma p‐tau immunoassays in clinical research for Alzheimer's disease

CE Teunissen, R Kolster, G Triana‐Baltzer… - Alzheimer's & …, 2025 - Wiley Online Library
The revised biomarker framework for diagnosis and staging of Alzheimer's disease (AD)
relies on amyloid beta (Aβ) and tau pathologies as core markers, and markers for adjacent …