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Blood-based biomarkers in Alzheimer's disease–moving towards a new era of diagnostics
Abstract Alzheimer's disease (AD), a primary cause of dementia globally, is traditionally
diagnosed via cerebrospinal fluid (CSF) measures and positron emission tomography …
diagnosed via cerebrospinal fluid (CSF) measures and positron emission tomography …
Diagnostic performance of plasma pTau217, pTau181, Aβ1-42 and Aβ1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease
J Arranz, N Zhu, S Rubio-Guerra… - Alzheimer's Research & …, 2024 - Springer
Background Recently developed blood markers for Alzheimer's disease (AD) detection have
high accuracy but usually require ultra-sensitive analytic tools not commonly available in …
high accuracy but usually require ultra-sensitive analytic tools not commonly available in …
[HTML][HTML] Blood-Based Biomarkers in Alzheimer's Disease: Advancing Non-Invasive Diagnostics and Prognostics
M Dhauria, R Mondal, S Deb, G Shome… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD), the most prevalent form of dementia, is expected to rise
dramatically in incidence due to the global population aging. Traditional diagnostic …
dramatically in incidence due to the global population aging. Traditional diagnostic …
Clinical evaluation of a novel plasma pTau217 electrochemiluminescence immunoassay in Alzheimer's disease
P Kivisäkk, HA Fatima, DS Cahoon, B Otieno… - Scientific Reports, 2024 - nature.com
A growing literature suggests that plasma levels of tau phosphorylated at amino acid 217
(pTau217) performs similarly to cerebrospinal fluid (CSF) biomarkers and PET imaging to …
(pTau217) performs similarly to cerebrospinal fluid (CSF) biomarkers and PET imaging to …
Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy individuals
INTRODUCTION Blood biomarkers have proven useful in Alzheimer's disease (AD)
research. However, little is known about their biological variation (BV), which improves the …
research. However, little is known about their biological variation (BV), which improves the …
Plasma p‐tau217, p‐tau181, and NfL as early indicators of dementia risk in a community cohort: the Shanghai Aging Study
Z **ao, W Wu, X Ma, J Wu, X Liang… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Blood biomarkers showed values for predicting future cognitive
impairment. Evidence from the community‐based cohort was limited only in high‐income …
impairment. Evidence from the community‐based cohort was limited only in high‐income …
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
S Lehmann, S Schraen-Maschke, JS Vidal… - Journal of Neurology …, 2024 - jnnp.bmj.com
Background Among plasma biomarkers for Alzheimer's disease (AD), pTau181 and
pTau217 are the most promising. However, transition from research to routine clinical use …
pTau217 are the most promising. However, transition from research to routine clinical use …
Plasma pTau181 Predicts Clinical Progression in a Phase 2 Randomized Controlled Trial of the 11β-HSD1 Inhibitor Xanamem® for Mild Alzheimer's Disease
J Taylor, M Jaros, C Chen… - Journal of Alzheimer's …, 2024 - journals.sagepub.com
Background: Blood biomarkers are proposed as a diagnostic alternative to amyloid PET or
cerebrospinal fluid (CSF) analyses for the diagnosis of Alzheimer's disease (AD). Relatively …
cerebrospinal fluid (CSF) analyses for the diagnosis of Alzheimer's disease (AD). Relatively …
Reactions of clinical neuropsychologists to the Alzheimer's Association workgroup's draft diagnostic and staging criteria for Alzheimer's disease
AM Kiselica, KJ Atkins, SD Han… - Journal of …, 2024 - journals.sagepub.com
Background An Alzheimer's Association (AA) workgroup published criteria for the diagnosis
and staging of Alzheimer's disease (AD). To date, there have not been empirical …
and staging of Alzheimer's disease (AD). To date, there have not been empirical …
Plasma p‐tau immunoassays in clinical research for Alzheimer's disease
CE Teunissen, R Kolster, G Triana‐Baltzer… - Alzheimer's & …, 2025 - Wiley Online Library
The revised biomarker framework for diagnosis and staging of Alzheimer's disease (AD)
relies on amyloid beta (Aβ) and tau pathologies as core markers, and markers for adjacent …
relies on amyloid beta (Aβ) and tau pathologies as core markers, and markers for adjacent …