The discovery of the Claisen rearrangement almost a century ago1 offered a potentially
useful synthetic tool to the organic chemist. Over the decades this usefulness has been …

The aromatic amino acids, phenylalanine, tyrosine, and tryptophan, are formed by a reaction
sequence leading from the two carbohydrate precursors, D-erythrose 4-phosphate and …

Solvent effects can significantly influence the structure and reactivity of organic compounds
in solution. 1 This is illustrated by the well-studied SN2 reactions, for which the reaction rates …

By combining the enormous molecular diversity of the immune system with basic
mechanistic principles of chemistry, one can produce catalytic antibodies that allow control …

The shikimic acid pathway is used by microorganisms to biosynthesize the aromatic amino
acids phenyl-alanine, tryptophan, and tyrosine, folate coenzymes, vitamins such as the …

The shikimate pathway has been described as a metabolic tree with many branches that led
to the synthesis of an extensive range of products. This pathway is present only in bacteria …

Density functional theory (DFT) has become a routine tool for the computation of electronic
structure in the physics, materials and chemistry fields. Yet the application of traditional DFT …

1 2 3 by at least 106-fold is not well understood, 2'3 and analysis has been complicated by
the existence of many different chorismate mutases with low sequence identity and unknown …

Structures have been determined for chorismate mutase from Bacillus subtilis and of
complexes of this enzyme with product and an endo-oxabicyclic transition state analog …

Mycobacterial arabinan is a common constituent of both arabinogalactan (AG) and
lipoarabinomannan (LAM). In this study, synthesis of β-Ara f containing common arabinan …