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Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport—an update
Q Mao, JD Unadkat - The AAPS journal, 2015 - Springer
The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
An overview of cannabidiol as a multifunctional drug: pharmacokinetics and cellular effects
Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis Sativa, has
garnered increasing attention for its diverse therapeutic potential. This comprehensive …
garnered increasing attention for its diverse therapeutic potential. This comprehensive …
[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …
thought to serve as simple energy storing molecules. More recently it has been realized that …
The role of retinoic acid in tolerance and immunity
Vitamin A elicits a broad array of immune responses through its metabolite, retinoic acid
(RA). Recent evidence indicates that loss of RA leads to impaired immunity, whereas excess …
(RA). Recent evidence indicates that loss of RA leads to impaired immunity, whereas excess …
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
K Natarajan, Y **e, MR Baer, DD Ross - Biochemical pharmacology, 2012 - Elsevier
Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …
Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression
T Nakanishi, DD Ross - Chinese journal of cancer, 2012 - pmc.ncbi.nlm.nih.gov
Breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …
Human ABCG2: structure, function, and its role in multidrug resistance
W Mo, JT Zhang - International journal of biochemistry and …, 2011 - pmc.ncbi.nlm.nih.gov
Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …
The role of transporters in the pharmacokinetics of orally administered drugs
S Shugarts, LZ Benet - Pharmaceutical research, 2009 - Springer
Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …
ABCG2: a perspective
ABCG2, or breast cancer resistance protein (BCRP), is an ABC transporter that has been the
subject of intense study since its discovery a decade ago. With high normal tissue …
subject of intense study since its discovery a decade ago. With high normal tissue …
Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development
Stem cells possess the dual properties of self‐renewal and pluripotency. Self‐renewal
affords these populations the luxury of self‐propagation, whereas pluripotency allows them …
affords these populations the luxury of self‐propagation, whereas pluripotency allows them …