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[HTML][HTML] Dendrimers in the context of nanomedicine
AP Dias, S da Silva Santos, JV da Silva… - International journal of …, 2020 - Elsevier
Dendrimers are globular structures, presenting an initiator core, repetitive layers starting
radially from the core and terminal groups on the surface, resembling tree architecture …
radially from the core and terminal groups on the surface, resembling tree architecture …
[HTML][HTML] Dendrimer prodrugs
S da Silva Santos, E Igne Ferreira, J Giarolla - Molecules, 2016 - mdpi.com
The main objective of this review is to describe the importance of dendrimer prodrugs in the
design of new drugs, presenting numerous applications of these nanocomposites in the …
design of new drugs, presenting numerous applications of these nanocomposites in the …
Drug/lead compound hydroxymethylation as a simple approach to enhance pharmacodynamic and pharmacokinetic properties
Hydroxymethylation is a simple chemical reaction, in which the introduction of the
hydroxymethyl group can lead to physical–chemical property changes and offer several …
hydroxymethyl group can lead to physical–chemical property changes and offer several …
How do physicochemical properties contribute to inhibitory activity of promising peptides against Zika Virus NS3 protease?
DF Savino, JV Silva, S da Silva Santos… - Journal of Molecular …, 2024 - Springer
Context and results Flavivirus diseases' cycles, especially Dengue and Yellow Fever, can be
observed all over Brazilian territory, representing a great health concern. Additionally, there …
observed all over Brazilian territory, representing a great health concern. Additionally, there …
Drug design for neglected disease in Brazil
J Giarolla, E Igne Ferreira - Mini Reviews in Medicinal Chemistry, 2015 - benthamdirect.com
Neglected tropical diseases (NTD) are a group of 17 diseases transmitted by virus, protozoa,
helminthes and bacteria. These illnesses are responsible for millions of deaths per year …
helminthes and bacteria. These illnesses are responsible for millions of deaths per year …
In silico study to analyse the disassembly of quercetin-targeted dendrimers potentially leishmanicide
S da Silva Santos, J Giarolla, KFM Pasqualoto… - Molecular …, 2015 - Taylor & Francis
Molecular modelling methods were previously applied to obtain information regarding the
disassembly of the first generation quercetin-targeted dendrimers potentially leishmanicide …
disassembly of the first generation quercetin-targeted dendrimers potentially leishmanicide …