Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost
researched tumour suppressor protein. It is commonly considered the “guardian of the …

Drug discovery is a costly and time-consuming process with a very high failure rate.
Recently, click chemistry and computer-aided drug design (CADD) represent popular areas …

Cancer, a leading global cause of death, necessitates the exploration of safer and more
effective anticancer drugs due to the adverse side effects associated with current cytotoxic …

In the current study, a novel compound, bis (3-(2H-benzo [d][1, 2, 3] triazol-2-yl)-2-(prop-2-yn-
1-yloxy)-5-(2, 4, 4-trimethylpentan-2-yl) phenyl) methane (TAJ1), has been synthesized by …

Twelve 2, 4-Bis substituted quinazoline based compounds were synthesized and screened
for antiproliferative and tubulin polymerization enhancing potential. In the series, compound …

Colchicine is a bioactive alkaloid originally from Colchicum autumnale and possesses
excellent antiproliferative activity. However, colchicine-associated severe toxicity …

Background Piperidines are among the essential synthetic fragments for designing drugs
and play a significant role in the pharmaceutical industry. The synthesis of newer derivatives …

Cancer is a disease in which some of the body's cells grow uncontrollably and spread to
other parts of the body. Cancer treatment usually involves the use of single or combined …

A facile one-step catalyst free methodology has been developed for the regioselective
functionalization of 4, 6-diphenylpyrimidin-2 (1H)-ones under mild conditions. Selectivity …

Design, Synthesis, Molecular Docking, In-vitro Anticancer and Antibacterial Evaluation of Novel
Pyrazole Linked with Quinazoline Page 1 ORIENTAL JOURNAL OF CHEMISTRY …