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How does DNA break during chromosomal translocations?
Chromosomal translocations are one of the most common types of genetic rearrangements
and are molecular signatures for many types of cancers. They are considered as primary …
and are molecular signatures for many types of cancers. They are considered as primary …
Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis
Naturally occurring compounds are considered as attractive candidates for cancer treatment
and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly …
and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly …
[HTML][HTML] An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression
DNA Ligase IV is responsible for sealing of double-strand breaks (DSBs) during
nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs …
nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs …
Nonhomologous end joining: new accessory factors fine tune the machinery
Nonhomologous DNA end joining (NHEJ) is one of the major DNA double-strand break
(DSB) repair pathways in eukaryotes. The well-known critical proteins involved in NHEJ …
(DSB) repair pathways in eukaryotes. The well-known critical proteins involved in NHEJ …
Homology and enzymatic requirements of microhomology-dependent alternative end joining
Nonhomologous DNA end joining (NHEJ) is one of the major double-strand break (DSB)
repair pathways in higher eukaryotes. Recently, it has been shown that alternative NHEJ (A …
repair pathways in higher eukaryotes. Recently, it has been shown that alternative NHEJ (A …
Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots
Obesity is associated with increased cancer risk, yet the underlying mechanisms remain
elusive. Obesity-associated cancers involve disruptions in metabolic and cellular pathways …
elusive. Obesity-associated cancers involve disruptions in metabolic and cellular pathways …
RNA-guided gene editing and gene regulation
2015-12-04 Assigned to DUKE UNIVERSITY reassignment DUKE UNIVERSITY
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions
Mitochondrial DNA (mtDNA) deletions are associated with various mitochondrial disorders.
The deletions identified in humans are flanked by short, directly repeated mitochondrial DNA …
The deletions identified in humans are flanked by short, directly repeated mitochondrial DNA …
Homologous recombination-mediated repair of DNA double-strand breaks operates in mammalian mitochondria
Mitochondrial DNA is frequently exposed to oxidative damage, as compared to nuclear
DNA. Previously, we have shown that while microhomology-mediated end joining can …
DNA. Previously, we have shown that while microhomology-mediated end joining can …
Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice
Background The consumption of berry fruits, including strawberries, has been suggested to
have beneficial effects against oxidative stress mediated diseases. Berries contain multiple …
have beneficial effects against oxidative stress mediated diseases. Berries contain multiple …